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Article

Interruption of glycosphingolipid synthesis enhances osteoarthritis development in mice

6 Mar 2012

Abstract excerpt

OBJECTIVE: Glycosphingolipids (GSLs) are ubiquitous membrane components that modulate transmembrane signaling and mediate cell-to-cell and cell-to-matrix interactions. GSL expression is decreased in the articular cartilage of humans with osteoarthritis (OA). This study was undertaken to determine the functional role of GSLs in cartilage metabolism related to OA pathogenesis in mice. METHODS: We generated mice...

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PMID: 22391889
DOI: 10.1002/art.34463

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