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Article

Xist ribonucleoproteins promote female sex-biased autoimmunity

2022-11-05

Abstract excerpt

<h4>SUMMARY</h4> Autoimmune diseases disproportionately affect females more than males. The XX sex chromosome complement is strongly associated with susceptibility to autoimmunity. Xist long noncoding RNA (lncRNA) is expressed only in females to randomly inactivate one of the two X chromosomes to achieve gene dosage compensation. Here, we show that the Xist ribonucleoprotein (RNP) complex, comprised of numerous a...

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Literature Corpus work
711994b7-248d-5d8a-9c0a-f3eb0900a9b4
DOI
10.1101/2022.11.05.515306
Open publication

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Xist ribonucleoproteins promote female sex-biased autoimmunityDOI 10.1101/2022.11.05.515306
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