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Article

Female-bias in systemic lupus erythematosus: How much is the X chromosome to blame?

7 Oct 2024

Abstract excerpt

Systemic lupus erythematosus (SLE or lupus) is an immune-mediated disease associated with substantial medical burden. Notably, lupus exhibits a striking female bias, with women having significantly higher susceptibility compared to men, up to 14-fold higher in some ethnicities. Supernumerary X chromosome syndromes, like Klinefelter (XXY) and Triple X syndrome (XXX), also present higher SLE prevalence, whereas...

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PMID: 39375734
DOI: 10.1186/s13293-024-00650-y

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