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Article

The XIST lncRNA is a sex-specific reservoir of TLR7 ligands in SLE

21 Sept 2023

Abstract excerpt

Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with a dramatic sex bias, affecting 9 times more women than men. Activation of Toll-like receptor 7 (TLR7) by self-RNA is a central pathogenic process leading to aberrant production of type I interferon (IFN) in SLE, but the specific RNA molecules that serve as TLR7 ligands have not been defined. By leveraging gene expression data and the known...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 37733447
DOI: 10.1172/jci.insight.169344

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