Article
Genomic rearrangements in inherited disease and cancer.
Seminars in cancer biology - 1 Aug 2010
Chen Jian-Min, Cooper David N, Férec Claude, Kehrer-Sawatzki Hildegard, Patrinos George P
Abstract excerpt
Genomic rearrangements in inherited disease and cancer involve gross alterations of chromosomes or large chromosomal regions and can take the form of deletions, duplications, insertions, inversions or translocations. The characterization of a considerable number of rearrangement breakpoints has now been accomplished at the nucleotide sequence level, thereby providing an invaluable resource for the detailed study...
Topics
- Chromosome Aberrations
- Genetic Diseases, Inborn
- Genome, Human
- Humans
- Models, Biological
- Mutation
- Neoplasms
- Recombination, Genetic
- Translocation, Genetic