Article
Human l1 retrotransposition is associated with genetic instability in vivo.
Cell - 9 Aug 2002
Symer David E, Connelly Carla, Szak Suzanne T, Caputo Emerita M, Cost Gregory J, Parmigiani Giovanni, Boeke Jef D
Abstract excerpt
Retrotransposons have shaped eukaryotic genomes for millions of years. To analyze the consequences of human L1 retrotransposition, we developed a genetic system to recover many new L1 insertions in somatic cells. Forty-two de novo integrants were recovered that faithfully mimic many aspects of L1s that accumulated since the primate radiation. Their structures experimentally demonstrate an association between L1...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.