Article
L1 recombination-associated deletions generate human genomic variation.
Proceedings of the National Academy of Sciences of the United States of America - 9 Dec 2008
Han Kyudong, Lee Jungnam, Meyer Thomas J, Remedios Paul, Goodwin Lindsey, Batzer Mark A
Abstract excerpt
Mobile elements have created structural variation in the human genome through their de novo insertions and post-insertional genomic rearrangements. L1 elements are a type of long interspersed element (LINE) that is dispersed at high copy numbers within most mammalian genomes. To determine the magnitude of L1 recombination-associated deletions (L1RADs), we computationally extracted L1RAD candidates by comparing...
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