Article

Mechanisms of insertions at a DNA double-strand break

2022-10-01

Abstract excerpt

Insertions and deletions (indels) are common sources of structural variation, and insertions originating from spontaneous DNA lesions are frequent in cancer. We developed a highly sensitive assay in human cells (Indel-Seq) to monitor rearrangements at the TRIM37 acceptor locus which reports indels stemming from experimentally-induced and spontaneous genome instability. Templated insertions derive from sequences ge...

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Literature Corpus work: 9ca6b760-c985-5d58-ab00-18189bc76a4d
DOI: 10.1101/2022.09.30.509517

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