Article

BubR1 recruitment to the kinetochore via Bub1 enhances Spindle Assembly Checkpoint signaling

2021-08-12

Abstract excerpt

During mitosis, unattached kinetochores in a dividing cell activate the Spindle Assembly Checkpoint (SAC) and delay anaphase onset by generating the anaphase-inhibitory Mitotic Checkpoint Complex (MCC). These kinetochores generate the MCC by recruiting MCC constituent proteins, including BubR1. In principle, BubR1 recruitment to signaling kinetochores should increase its local concentration and promote MCC formati...

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Literature Corpus work: 12dbd599-4951-5e2d-bf08-6746f144ed81
DOI: 10.1101/2021.08.12.456107

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