Article
Recruitment of Cdc20 to the kinetochore requires BubR1 but not Mad2 in Drosophila melanogaster.
Molecular and cellular biology - 1 Jul 2010
Li Deyu, Morley Gary, Whitaker Michael, Huang Jun-Yong
Abstract excerpt
To prevent aneuploidy, cells require a mitotic surveillance mechanism, the spindle assembly checkpoint (SAC). The SAC prevents metaphase/anaphase transition by blocking the ubiquitylation and destruction of cyclin B and securin via the Cdc20-activated anaphase-promoting complex or cyclosome (APC/C)-mediated proteolysis pathway. This checkpoint involves the kinetochore proteins Mad2, BubR1, and Cdc20. Mad2 and...
Topics
- Amino Acid Sequence
- Animals
- Cdc20 Proteins
- Cell Cycle
- Cell Cycle Proteins
- Colchicine
- Drosophila Proteins
- Drosophila melanogaster
- Embryo, Nonmammalian
- Humans
- Kinetochores
- Mad2 Proteins
- Molecular Sequence Data
- Mutation
- RNA Interference
- Recombinant Fusion Proteins
- Sequence Alignment
- Spindle Apparatus