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Article

The internal Cdc20 binding site in BubR1 facilitates both spindle assembly checkpoint signalling and silencing.

Nature communications - 8 Dec 2014

Lischetti Tiziana, Zhang Gang, Sedgwick Garry G, Bolanos-Garcia Victor M, Nilsson Jakob

Abstract excerpt

Improperly attached kinetochores activate the spindle assembly checkpoint (SAC) and by an unknown mechanism catalyse the binding of two checkpoint proteins, Mad2 and BubR1, to Cdc20 forming the mitotic checkpoint complex (MCC). Here, to address the functional role of Cdc20 kinetochore localization in the SAC, we delineate the molecular details of its interaction with kinetochores. We find that BubR1 recruits the...

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Source

Identifiers

PMID: 25482201
DOI: 10.1038/ncomms6563

Genes

MCC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The internal Cdc20 binding site in BubR1 facilitates both spindle assembly checkpoint signalling and silencing.PMID 25482201Read ↗

Bimodal activation of BubR1 by Bub3 sustains mitotic checkpoint signaling.Semantic proximity Read ↗

Recruitment of Cdc20 to the kinetochore requires BubR1 but not Mad2 in Drosophila melanogaster.Semantic proximity Read ↗

BubR1 recruitment to the kinetochore via Bub1 enhances Spindle Assembly Checkpoint signalingSemantic proximity Read ↗

The Mitotic Checkpoint Complex Requires an Evolutionary Conserved Cassette to Bind and Inhibit Active APC/C.Semantic proximity Read ↗

The Bub1-Plk1 kinase complex promotes spindle checkpoint signalling through Cdc20 phosphorylation.Semantic proximity Read ↗

Uncoupling of the spindle-checkpoint and chromosome-congression functions of BubR1.Semantic proximity Read ↗

Drosophila CENP-A mutations cause a BubR1-dependent early mitotic delay without normal localization of kinetochore components.Semantic proximity Read ↗

BUB1 and BUBR1: multifaceted kinases of the cell cycle.Semantic proximity Read ↗

Laterally attached kinetochores recruit the checkpoint protein Bub1, but satisfy the spindle checkpoint.Semantic proximity Read ↗

Two complexes of spindle checkpoint proteins containing Cdc20 and Mad2 assemble during mitosis independently of the kinetochore in Saccharomyces cerevisiae.Semantic proximity Read ↗

Histone H3K4 methylation regulates deactivation of the spindle assembly checkpoint through direct binding of Mad2.Semantic proximity Read ↗

Bub1 regulates chromosome segregation in a kinetochore-independent manner.Semantic proximity Read ↗

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