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Article

Bimodal activation of BubR1 by Bub3 sustains mitotic checkpoint signaling.

Proceedings of the National Academy of Sciences of the United States of America - 7 Oct 2014

Han Joo Seok, Vitre Benjamin, Fachinetti Daniele, Cleveland Don W

Abstract excerpt

The mitotic checkpoint (also known as the spindle assembly checkpoint) prevents premature anaphase onset through generation of an inhibitor of the E3 ubiquitin ligase APC/C, whose ubiquitination of cyclin B and securin targets them for degradation. Combining in vitro reconstitution and cell-based assays, we now identify dual mechanisms through which Bub3 promotes mitotic checkpoint signaling. Bub3 enhances...

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PMID: 25246557
DOI: 10.1073/pnas.1416277111
PMCID: PMC4210015

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APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Bimodal activation of BubR1 by Bub3 sustains mitotic checkpoint signaling.PMID 25246557Read ↗

The Bub1-Plk1 kinase complex promotes spindle checkpoint signalling through Cdc20 phosphorylation.Semantic proximity Read ↗

BUB1 and BUBR1: multifaceted kinases of the cell cycle.Semantic proximity Read ↗

Recruitment of Cdc20 to the kinetochore requires BubR1 but not Mad2 in Drosophila melanogaster.Semantic proximity Read ↗

BubR1 recruitment to the kinetochore via Bub1 enhances Spindle Assembly Checkpoint signalingSemantic proximity Read ↗

The internal Cdc20 binding site in BubR1 facilitates both spindle assembly checkpoint signalling and silencing.Semantic proximity Read ↗

Saccharomyces cerevisiae BUB2 prevents mitotic exit in response to both spindle and kinetochore damage.Semantic proximity Read ↗

The spindle checkpoint functions of Mad3 and Mad2 depend on a Mad3 KEN box-mediated interaction with Cdc20-anaphase-promoting complex (APC/C).Semantic proximity Read ↗

Two complexes of spindle checkpoint proteins containing Cdc20 and Mad2 assemble during mitosis independently of the kinetochore in Saccharomyces cerevisiae.Semantic proximity Read ↗

BubR1 kinase: protection against aneuploidy and premature aging.Semantic proximity Read ↗

Uncoupling of the spindle-checkpoint and chromosome-congression functions of BubR1.Semantic proximity Read ↗

The Mitotic Checkpoint Complex Requires an Evolutionary Conserved Cassette to Bind and Inhibit Active APC/C.Semantic proximity Read ↗

Mad3p, a pseudosubstrate inhibitor of APCCdc20 in the spindle assembly checkpoint.Semantic proximity Read ↗

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