Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Mitotic Checkpoint Complex Requires an Evolutionary Conserved Cassette to Bind and Inhibit Active APC/C.

Molecular cell - 15 Dec 2016

Di Fiore Barbara, Wurzenberger Claudia, Davey Norman E, Pines Jonathon

Abstract excerpt

The Spindle Assembly Checkpoint (SAC) ensures genomic stability by preventing sister chromatid separation until all chromosomes are attached to the spindle. It catalyzes the production of the Mitotic Checkpoint Complex (MCC), which inhibits Cdc20 to inactivate the Anaphase Promoting Complex/Cyclosome (APC/C). Here we show that two Cdc20-binding motifs in BubR1 of the recently identified ABBA motif class are...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Motifs
Share to Anaphase-Promoting Complex-Cyclosome

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Caenorhabditis elegans

Share to Cdc20 Proteins

Share to Conserved Sequence

Share to HeLa Cells

Share to M Phase Cell Cycle Checkpoints

Share to Time-Lapse Imaging

Source

Open in PubMed Open full text

Identifiers

PMID: 27939943
DOI: 10.1016/j.molcel.2016.11.006
PMCID: PMC5179498

Genes

APC
MCC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Mitotic Checkpoint Complex Requires an Evolutionary Conserved Cassette to Bind and Inhibit Active APC/C.PMID 27939943Read ↗

Phylogenomics-guided discovery of a novel conserved cassette of short linear motifs in BubR1 essential for the spindle checkpointSemantic proximity Read ↗

The Bub1-Plk1 kinase complex promotes spindle checkpoint signalling through Cdc20 phosphorylation.Semantic proximity Read ↗

Uncoupling of the spindle-checkpoint and chromosome-congression functions of BubR1.Semantic proximity Read ↗

Drosophila CENP-A mutations cause a BubR1-dependent early mitotic delay without normal localization of kinetochore components.Semantic proximity Read ↗

The vertebrate mitotic checkpoint protein BUBR1 is an unusual pseudokinase.Semantic proximity Read ↗

BUB1 and BUBR1: multifaceted kinases of the cell cycle.Semantic proximity Read ↗

Recruitment of Cdc20 to the kinetochore requires BubR1 but not Mad2 in Drosophila melanogaster.Semantic proximity Read ↗

KEN-box-dependent degradation of the Bub1 spindle checkpoint kinase by the anaphase-promoting complex/cyclosome.Semantic proximity Read ↗

The internal Cdc20 binding site in BubR1 facilitates both spindle assembly checkpoint signalling and silencing.Semantic proximity Read ↗

Bimodal activation of BubR1 by Bub3 sustains mitotic checkpoint signaling.Semantic proximity Read ↗

The spindle checkpoint functions of Mad3 and Mad2 depend on a Mad3 KEN box-mediated interaction with Cdc20-anaphase-promoting complex (APC/C).Semantic proximity Read ↗

Bub1: Escapades in a Cellular WorldSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.