Article
MPS1/Mph1 phosphorylates the kinetochore protein KNL1/Spc7 to recruit SAC components.
Nature cell biology - 3 Jun 2012
Yamagishi Yuya, Yang Ching-Hui, Tanno Yuji, Watanabe Yoshinori
Abstract excerpt
The genomic stability of all organisms depends on the precise partition of chromosomes to daughter cells. The spindle assembly checkpoint (SAC) senses unattached kinetochores and prevents premature entry to anaphase, thus ensuring that all chromosomes attach to opposite spindle poles (bi-orientat...
Topics
- Cell Cycle Proteins
- Chromosomal Proteins, Non-Histone
- Chromosome Segregation
- Kinetochores
- M Phase Cell Cycle Checkpoints
- Mad2 Proteins
- Mutation
- Nuclear Proteins
- Phosphorylation
- Protein Binding
- Protein Kinases
- Protein Serine-Threonine Kinases
- Recombinant Fusion Proteins
- Schizosaccharomyces
- Schizosaccharomyces pombe Proteins
- Time Factors