Article
Uncoupling of the spindle-checkpoint and chromosome-congression functions of BubR1.
Journal of cell science - 1 Jan 2010
Elowe Sabine, Dulla Kalyan, Uldschmid Andreas, Li Xiuling, Dou Zhen, Nigg Erich A
Abstract excerpt
The BubR1 checkpoint protein performs multiple functions in mitosis. We have carried out a functional analysis of conserved motifs of human BubR1 (also known as BUB1B) and demonstrate that spindle assembly checkpoint (SAC) and chromosome attachment functions can be uncoupled from each other. Muta...
Topics
- Amino Acid Motifs
- CDC2 Protein Kinase
- Cdc20 Proteins
- Cell Cycle Proteins
- Cysteine Proteinase Inhibitors
- Genes, cdc
- HeLa Cells
- Humans
- Kinetochores
- Leupeptins
- Mitosis
- Mutation
- Nocodazole
- Phosphorylation
- Protein Binding
- Protein Serine-Threonine Kinases
- Protein Transport
- Spindle Apparatus