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Article

Uncoupling of the spindle-checkpoint and chromosome-congression functions of BubR1.

Journal of cell science - 1 Jan 2010

Elowe Sabine, Dulla Kalyan, Uldschmid Andreas, Li Xiuling, Dou Zhen, Nigg Erich A

Abstract excerpt

The BubR1 checkpoint protein performs multiple functions in mitosis. We have carried out a functional analysis of conserved motifs of human BubR1 (also known as BUB1B) and demonstrate that spindle assembly checkpoint (SAC) and chromosome attachment functions can be uncoupled from each other. Mutation of five proline-directed serine phosphorylation sites, identified in vivo by mass spectrometry, essentially...

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PMID: 20016069
DOI: 10.1242/jcs.056507

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APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Uncoupling of the spindle-checkpoint and chromosome-congression functions of BubR1.PMID 20016069Read ↗

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Biallelic BUB1 mutations cause microcephaly, developmental delay, and variable effects on cohesion and chromosome segregation.Semantic proximity Read ↗

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