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Article

Mph1 kinetochore localization is crucial and upstream in the hierarchy of spindle assembly checkpoint protein recruitment to kinetochores.

Journal of cell science - 15 Oct 2012

Heinrich Stephanie, Windecker Hanna, Hustedt Nicole, Hauf Silke

Abstract excerpt

The spindle assembly checkpoint (SAC) blocks entry into anaphase until all chromosomes have stably attached to the mitotic spindle through their kinetochores. The checkpoint signal originates from unattached kinetochores, where there is an enrichment of SAC proteins. Whether the enrichment of all SAC proteins is crucial for SAC signaling is unclear. Here, we provide evidence that, in fission yeast, recruitment of...

Topics

Aurora Kinases
Cell Cycle Proteins
Kinetochores
M Phase Cell Cycle Checkpoints
Mutation
Protein Kinases
Protein Serine-Threonine Kinases
Schizosaccharomyces
Schizosaccharomyces pombe Proteins
Signal Transduction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22825872
DOI: 10.1242/jcs.110387

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-22825872-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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