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Article

Synthetic Physical Interactions Map Kinetochore-Checkpoint Activation Regions.

G3 (Bethesda, Md.) - 9 Aug 2016

Ólafsson Guðjón, Thorpe Peter H

Abstract excerpt

The spindle assembly checkpoint (SAC) is a key mechanism to regulate the timing of mitosis and ensure that chromosomes are correctly segregated to daughter cells. The recruitment of the Mad1 and Mad2 proteins to the kinetochore is normally necessary for SAC activation. This recruitment is coordinated by the SAC kinase Mps1, which phosphorylates residues at the kinetochore to facilitate binding of Bub1, Bub3,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Kinetochores

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Source

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Identifiers

PMID: 27280788
DOI: 10.1534/g3.116.031930
PMCID: PMC4978906

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Synthetic Physical Interactions Map Kinetochore-Checkpoint Activation Regions.PMID 27280788Read ↗

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Dissection of the Spindle Assembly Checkpoint by Proximity ProteomicsSemantic proximity Read ↗

Synthetic physical interactions map kinetochore regulators and regions sensitive to constitutive Cdc14 localization.Semantic proximity Read ↗

MPS1/Mph1 phosphorylates the kinetochore protein KNL1/Spc7 to recruit SAC components.Semantic proximity Read ↗

Spindle checkpoint-independent inhibition of mitotic chromosome segregation by Drosophila Mps1.Semantic proximity Read ↗

Bub3 reads phosphorylated MELT repeats to promote spindle assembly checkpoint signaling.Semantic proximity Read ↗

The C-terminal half of Saccharomyces cerevisiae Mad1p mediates spindle checkpoint function, chromosome transmission fidelity and CEN association.Semantic proximity Read ↗

Mps1 promotes chromosome meiotic chromosome biorientation through Dam1.Semantic proximity Read ↗

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Mps1 phosphorylates Borealin to control Aurora B activity and chromosome alignment.Semantic proximity Read ↗

BubR1 recruitment to the kinetochore via Bub1 enhances Spindle Assembly Checkpoint signalingSemantic proximity Read ↗

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