Article

The histone demethylase HR suppresses breast cancer development through enhanced CELF2 tumor suppressor activity

2022-05-26

Abstract excerpt

<title>Abstract</title> <p>The hairless (HR) gene encodes a transcription factor with histone demethylase activity that is essential for development and tissue homeostasis. Previous studies suggest that mutational inactivation of HR promotes tumorigenesis. To investigate HR mutations in breast cancer, we performed targeted next-gen sequencing using DNA isolated from primary breast cancer tissues. We identified HR...

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Literature Corpus work: 12c4fb77-4e6f-58e9-a352-cba6ac681446
DOI: 10.21203/rs.3.rs-1639413/v1

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