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Article

The therapeutic potential of targeting the CHD protein family in cancer.

Pharmacology & therapeutics - 1 Apr 2024

Zhang Min, Wu Kaiyuan, Zhang Weijie, Lin Xia, Cao Qi, Zhang Lili, Chen Kaifu

Abstract excerpt

Accumulating evidence indicates that epigenetic events undergo deregulation in various cancer types, playing crucial roles in tumor development. Among the epigenetic factors involved in the epigenetic remodeling of chromatin, the chromodomain helicase DNA-binding protein (CHD) family frequently exhibits gain- or loss-of-function mutations in distinct cancer types. Therefore, targeting CHD remodelers holds the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38367868
DOI: 10.1016/j.pharmthera.2024.108610
PMCID: PMC10942663

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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