Article
Hairless regulates p53 target genes to exert tumor suppressive functions in glioblastoma.
Journal of cellular biochemistry - 1 Jan 2019
Brook Lemlem, Palade Patricia, Maatough Anas, Whitfield Graham Kerr, Emeterio Lis San, Hsieh David, Hsieh Jui-Cheng
Abstract excerpt
Glioblastoma (GBM) is the most common malignant brain tumor and is associated with a poor prognosis, with most patients living less than a year after diagnosis. Given that GBM nearly always recurs after conventional treatments, there is an urgent need to identify novel molecular targets. Hairless (HR) is a nuclear factor enriched in the skin and has been previously implicated in hair cycling. HR is also highly...
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