Article
Pan-Cancer Multi-Omics Analysis Uncovers CHD4 Driving Tumor Progression via Epigenetic Regulation of Genomic Stability and the Immune Microenvironment
2025-12-30
Abstract excerpt
<title>Abstract</title> <p>Background Chromodomain Helicase DNA-Binding Protein 4 (CHD4), the core ATPase subunit of the NuRD complex, plays a critical role in epigenetic regulation. However, its systematic function across pan-cancer contexts and the synergistic regulatory mechanisms governing genomic stability and the immune microenvironment remain poorly characterized. Methods This study analyzed the expressi...
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Identifiers and source
- Literature Corpus work
- c156c7b5-4b30-5c72-821f-25082ad06709
- DOI
- 10.21203/rs.3.rs-8358598/v1