Article

Low E2F2 activity is associated with high genomic instability and PARPi resistance

2019-10-03

Abstract excerpt

The E2F family, classically known for a central role in cell cycle, has a number of emerging roles in cancer including angiogenesis, metabolic reprogramming, metastasis and DNA repair. E2F1 specifically has been shown to be a critical mediator of DNA repair; however, little is known about DNA repair and other E2F family members. Here we present an integrative bioinformatic and high throughput drug screening study...

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Literature Corpus work: 37cb6fe5-500a-57d0-87ee-7998dfacc430
DOI: 10.1101/777870

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