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Article

Hairless is a histone H3K9 demethylase.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Apr 2014

Liu Liang, Kim Hyunmi, Casta Alex, Kobayashi Yuki, Shapiro Lawrence S, Christiano Angela M

Abstract excerpt

The hairless (HR) protein contains a Jumonji C (JmjC) domain that is conserved among a family of proteins with histone demethylase (HDM) activity. To test whether HR possesses HDM activity, we performed a series of in vitro demethylation assays, which demonstrated that HR can demethylate monomethylated or dimethylated histone H3 lysine 9 (H3K9me1 or me2). Moreover, ectopic expression of wild-type HR, but not...

Topics

Basic Helix-Loop-Helix Transcription Factors
Binding Sites
Blotting, Western
Caspase 14
Cells, Cultured
Chromatin Immunoprecipitation
Gene Expression Regulation
HEK293 Cells
HeLa Cells
Histone Demethylases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Histones

Humans

Jumonji Domain-Containing Histone Demethylases

Lysine

Methylation

Models, Molecular

Mutation

Promoter Regions, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 24334705
DOI: 10.1096/fj.13-237677
PMCID: PMC3963012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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