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Article

Hairless is a histone H3K9 demethylase.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Apr 2014

Liu Liang, Kim Hyunmi, Casta Alex, Kobayashi Yuki, Shapiro Lawrence S, Christiano Angela M

Abstract excerpt

The hairless (HR) protein contains a Jumonji C (JmjC) domain that is conserved among a family of proteins with histone demethylase (HDM) activity. To test whether HR possesses HDM activity, we performed a series of in vitro demethylation assays, which demonstrated that HR can demethylate monomethylated or dimethylated histone H3 lysine 9 (H3K9me1 or me2). Moreover, ectopic expression of wild-type HR, but not...

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Identifiers

PMID: 24334705
DOI: 10.1096/fj.13-237677
PMCID: PMC3963012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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