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Article

GRHL2-controlled gene expression networks in luminal breast cancer

23 Jan 2023

Abstract excerpt

Grainyhead like 2 (GRHL2) is an essential transcription factor for development and function of epithelial tissues. It has dual roles in cancer by supporting tumor growth while suppressing epithelial to mesenchymal transitions (EMT). GRHL2 cooperates with androgen and estrogen receptors (ER) to regulate gene expression. We explore genome wide GRHL2 binding sites conserved in three ER⍺/GRHL2 positive luminal breast...

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PMID: 36691073
DOI: 10.1186/s12964-022-01029-5

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