Article
Mutational Landscape and Antiproliferative Functions of ELF Transcription Factors in Human Cancer.
Cancer research - 1 Apr 2016
Ando Mizuo, Kawazu Masahito, Ueno Toshihide, Koinuma Daizo, Ando Koji, Koya Junji, Kataoka Keisuke, Yasuda Takahiko, Yamaguchi Hiroyuki, Fukumura Kazutaka, Yamato Azusa, Soda Manabu, Sai Eirin, Yamashita Yoshihiro, Asakage Takahiro, Miyazaki Yasushi, Kurokawa Mineo, Miyazono Kohei, Nimer Stephen D, Yamasoba Tatsuya, Mano Hiroyuki
Abstract excerpt
ELF4 (also known as MEF) is a member of the ETS family of transcription factors. An oncogenic role for ELF4 has been demonstrated in hematopoietic malignancies, but its function in epithelial tumors remains unclear. Here, we show that ELF4 can function as a tumor suppressor and is somatically inactivated in a wide range of human tumors. We identified a missense mutation affecting the transactivation potential of...
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