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Article

Grainyhead-like 2 (GRHL2) inhibits keratinocyte differentiation through epigenetic mechanism

20 Dec 2012

Abstract excerpt

We recently identified Grainyhead-like 2 (GRHL2), a mammalian homolog of Grainyhead in Drosophila, to be a novel transcription factor that regulates hTERT gene expression and enhances proliferation of normal human epidermal keratinocytes (NHEK). In the current study, we show that GRHL2 impairs keratinocyte differentiation through transcriptional inhibition of the genes clustered at the epidermal differentiation...

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PMID: 23254293
DOI: 10.1038/cddis.2012.190

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