<i>In Vivo</i> Disruption of an Rb–E2F–Ezh2 Signaling Loop Causes Bladder Cancer

Abstract excerpt

Bladder cancer is a highly prevalent human disease in which retinoblastoma (Rb) pathway inactivation and epigenetic alterations are common events. However, the connection between these two processes is still poorly understood. Here, we show that the in vivo inactivation of all Rb family genes in the mouse urothelium is sufficient to initiate bladder cancer development. The characterization of the mouse tumors...

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