Article

TREM2 deficiency causes region-specific brain effects in a mouse model of cerebral amyloid angiopathy

2026-04-19

Abstract excerpt

<h4>ABSTRACT</h4> Cerebral amyloid angiopathy (CAA), a major vascular contributor to cognitive decline, is present in 85–95% of Alzheimer’s disease (AD) patients. Despite its high prevalence, the mechanisms by which CAA contributes to neurodegeneration remain poorly understood. Triggering receptor expressed on myeloid cells 2 (TREM2), an innate immune receptor expressed exclusively by microglia, regulates activat...

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Literature Corpus work: 1285b9b8-89ad-56be-a7e6-58de54961689
DOI: 10.64898/2026.04.17.719285

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