Article

Loss of Trem2 in microglia leads to widespread disruption of cell co-expression networks in mouse brain

2018-01-17

Abstract excerpt

Rare heterozygous coding variants in the Triggering Receptor Expressed in Myeloid cells 2 (TREM2) gene, conferring increased risk of developing late-onset Alzheimer's disease, have been identified. We examined the transcriptional consequences of the loss of Trem2 in mouse brain to better understand its role in disease using differential expression and coexpression network analysis of Trem2 knockout and wild-type m...

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Literature Corpus work: b96ecfdb-5274-546e-bdbe-3a424d7af1e5
DOI: 10.1101/248757

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