Article

Loss of TREM2 exacerbates parenchymal amyloid pathology but diminishes CAA in Tg-SwDI mice

2023-11-05

Abstract excerpt

Alzheimer’s disease (AD) is a progressive neurodegenerative disease, and it is the most common cause of dementia worldwide. Recent genome-wide association studies (GWAS) identified TREM2 (triggering receptor expressed on myeloid cells 2) as one of the major risk factors for AD. TREM2 is a surface receptor expressed on microglia and largely mediates microglial functions and immune homeostasis in the brain. The func...

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Literature Corpus work: 33d0fb34-0d4b-5a55-a254-ee07ff819e6c
DOI: 10.1101/2023.11.04.565659

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