Article

Histone demethylase KDM5 regulates cardiomyocyte maturation by promoting fatty acid oxidation, oxidative phosphorylation, and myofibrillar organization

2023-04-11

Abstract excerpt

<h4>Rationale</h4> Human pluripotent stem cell-derived CMs (iPSC-CMs) are a valuable tool for disease modeling, cell therapy and to reconstruct the CM maturation process and identify, characterize factors that regulate maturation. The transition from immature fetal to adult CM entails coordinated regulation of the mature gene programming, which is characterized by the induction of myofilament and OXPHOS gene expr...

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Literature Corpus work: 12633783-c3b6-5215-bcae-1557019d4f46
DOI: 10.1101/2023.04.11.535169

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