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Screening of histone modulators small molecule library reveals Kdm5b as a major epigenetic modulator of cell cycle gene expression in cardiomyocytes

2026-02-04

Abstract excerpt

<h4>Background: </h4> and purpose: Cardiomyocyte (CM) cell cycle exit following neonatal stages positively correlates with epigenetic reprogramming that driving postnatal maturation as defined by increased rigidity of the sarcomere and metabolic reprogramming. However, till date, the epigenetic driver(s) for such process has not been identified. In this study, through a small molecule screening, we defined the his...

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Literature Corpus work
e0983b69-10c4-5298-8b31-b4a0c8ba311d
DOI
10.22541/au.177023174.46125188/v1
Open publication

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Screening of histone modulators small molecule library reveals Kdm5b as a major epigenetic modulator of cell cycle gene expression in cardiomyocytesDOI 10.22541/au.177023174.46125188/v1
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