Article

In vivo CRISPR screening identifies RNF20/40 as epigenetic regulators of cardiomyocyte maturation

2019-10-17

Abstract excerpt

<h4>ABSTRACT</h4> Between birth and adulthood cardiomyocytes (CMs) undergo dramatic changes in size, ultrastructure, metabolism, and gene expression, in a process collectively referred to as CM maturation. The transcriptional network that coordinates CM maturation is poorly understood, creating a bottleneck for cardiac regenerative medicine. Forward genetic screens are a powerful, unbiased method to gain novel in...

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Literature Corpus work: a503a3e8-cad6-5db5-a366-d9f8e586cb61
DOI: 10.1101/808402

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