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Article

Inhibition of fatty acid oxidation enables heart regeneration in adult mice.

Nature - 1 Oct 2023

Li Xiang, Wu Fan, Günther Stefan, Looso Mario, Kuenne Carsten, Zhang Ting, Wiesnet Marion, Klatt Stephan, Zukunft Sven, Fleming Ingrid, Poschet Gernot, Wietelmann Astrid, Atzberger Ann, Potente Michael, Yuan Xuejun, Braun Thomas

Abstract excerpt

Postnatal maturation of cardiomyocytes is characterized by a metabolic switch from glycolysis to fatty acid oxidation, chromatin reconfiguration and exit from the cell cycle, instating a barrier for adult heart regeneration1,2. Here, to explore whether metabolic reprogramming can overcome this barrier and enable heart regeneration, we abrogate fatty acid oxidation in cardiomyocytes by inactivation of Cpt1b. We...

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Identifiers

PMID: 37758950
DOI: 10.1038/s41586-023-06585-5
PMCID: PMC10584682

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