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Article

Multi-Omics Profiling of Hypertrophic Cardiomyopathy Reveals Altered Mechanisms in Mitochondrial Dynamics and Excitation-Contraction Coupling.

International journal of molecular sciences - 1 Mar 2023

Moore Jarrod, Ewoldt Jourdan, Venturini Gabriela, Pereira Alexandre C, Padilha Kallyandra, Lawton Matthew, Lin Weiwei, Goel Raghuveera, Luptak Ivan, Perissi Valentina, Seidman Christine E, Seidman Jonathan, Chin Michael T, Chen Christopher, Emili Andrew

Abstract excerpt

Hypertrophic cardiomyopathy is one of the most common inherited cardiomyopathies and a leading cause of sudden cardiac death in young adults. Despite profound insights into the genetics, there is imperfect correlation between mutation and clinical prognosis, suggesting complex molecular cascades driving pathogenesis. To investigate this, we performed an integrated quantitative multi-omics (proteomic,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36902152
DOI: 10.3390/ijms24054724
PMCID: PMC10002553

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