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Article

A transcriptional enhancer regulates cardiac maturation.

Nature cardiovascular research - 1 Jun 2024

Htet Myo, Lei Shunyao, Bajpayi Sheetal, Gangrade Harshi, Arvanitis Marios, Zoitou Asimina, Murphy Sean, Chen Elaine Zhelan, Koleini Navid, Lin Brian Leei, Kwon Chulan, Tampakakis Emmanouil

Abstract excerpt

Cardiomyocyte maturation is crucial for generating adult cardiomyocytes and the application of human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs). However, regulation at the cis-regulatory element level and its role in heart disease remain unclear. Alpha-actinin 2 (ACTN2) levels increase during CM maturation. In this study, we investigated a clinically relevant, conserved ACTN2 enhancer's effects on CM...

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Share to Cell Differentiation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enhancer Elements, Genetic

Share to Gene Expression Regulation, Developmental

Share to HSP90 Heat-Shock Proteins

Share to Myocytes, Cardiac

Share to TOR Serine-Threonine Kinases

Share to Transcription, Genetic

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Identifiers

PMID: 39196225
DOI: 10.1038/s44161-024-00484-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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