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Article

Massively parallel in vivo CRISPR screening identifies RNF20/40 as epigenetic regulators of cardiomyocyte maturation.

Nature communications - 21 Jul 2021

VanDusen Nathan J, Lee Julianna Y, Gu Weiliang, Butler Catalina E, Sethi Isha, Zheng Yanjiang, King Justin S, Zhou Pingzhu, Suo Shengbao, Guo Yuxuan, Ma Qing, Yuan Guo-Cheng, Pu William T

Abstract excerpt

The forward genetic screen is a powerful, unbiased method to gain insights into biological processes, yet this approach has infrequently been used in vivo in mammals because of high resource demands. Here, we use in vivo somatic Cas9 mutagenesis to perform an in vivo forward genetic screen in mice to identify regulators of cardiomyocyte (CM) maturation, the coordinated changes in phenotype and gene expression...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34290256
DOI: 10.1038/s41467-021-24743-z
PMCID: PMC8295283

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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