Article

The Epigenetic Regulator Histone Demethylase KDM5A is Activated and Pathogenic in a Mouse Model of Heart Failure

2026-01-06

Abstract excerpt

Heart failure is a complex disease characterized by the dysregulation of gene expression that culminates in cardiac dysfunction. Epigenetic regulators play a critical role in control of transcription and are increasingly implicated in the pathogenesis of heart failure. We recently showed that the histone demethylase KDM5A is reactivated in the heart of human patients and mouse models of heart failure. However, its...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 75128887-728b-50f7-becf-917d1f09ef5c
DOI: 10.64898/2026.01.05.697798

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The Epigenetic Regulator Histone Demethylase KDM5A is Activated and Pathogenic in a Mouse Model of Heart FailureDOI 10.64898/2026.01.05.697798Read

Loss of KDM5B ameliorates pathological cardiac fibrosis and dysfunction by epigenetically enhancing ATF3 expressionSemantic proximity Read

KDM8 epigenetically controls cardiac metabolism to prevent initiation of dilated cardiomyopathySemantic proximity Read

Histone demethylase KDM5 regulates cardiomyocyte maturation by promoting fatty acid oxidation, oxidative phosphorylation, and myofibrillar organizationSemantic proximity Read

Histone H4K20 Trimethylation is Decreased in Murine Models of Heart DiseaseSemantic proximity Read

RNA Helicase DDX5 Maintains Cardiac Function by Regulating CamkIIδ Alternative SplicingSemantic proximity Read

The chromatin-binding protein Smyd1 restricts adult mammalian heart growthSemantic proximity Read

Unravelling the impact of RNA methylation genetic and epigenetic machinery in the treatment of cardiomyopathySemantic proximity Read

Histone lysine demethylase inhibition is a disease-modifying therapy for hypertrophic cardiomyopathySemantic proximity Read

Haematopoietic loss of KDM6A impairs cardiac recovery in heart failure <i>via</i> epigenetic reprogramming of myeloid cellsSemantic proximity Read

Depletion of m6A reader protein YTHDC1 induces dilated cardiomyopathy by abnormal splicing of TitinSemantic proximity Read

Identification of Genes and Pathways Regulated by Lamin A in Heart.Semantic proximity Read

Loss of H3K4 methylation destabilizes gene expression patterns and physiological functions in adult murine cardiomyocytesSemantic proximity Read