Article

Isthmin-1 is a Key Regulator of Induced Pluripotent Stem Cell–Derived Cardiomyocytes Maturation through Activation of p53 Signaling

2026-01-09

Abstract excerpt

<h4>Aims</h4> Human induced pluripotent stem cell–derived cardiomyocytes (iPSC-CMs) exhibit an immature structural and metabolic phenotype that limits their utility for cardiac disease modeling and regenerative therapy. Although multiple extrinsic strategies have been proposed to enhance iPSC-CM maturation, intrinsic molecular regulators governing this process remain incompletely defined. This study aimed to iden...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: efe1d7e9-5659-5166-affd-8edc65b67606
DOI: 10.64898/2026.01.08.698535

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Isthmin-1 is a Key Regulator of Induced Pluripotent Stem Cell–Derived Cardiomyocytes Maturation through Activation of p53 SignalingDOI 10.64898/2026.01.08.698535Read

Multi-omic analysis reveals maturation programs in human pluripotent stem cell-derived cardiomyocytes during long-term cultureSemantic proximity Read

Nrf2 is required for structural and metabolic maturation of human induced pluripotent stem cell-derived cardiomyocytesSemantic proximity Read

Molecular Rewiring in TNNT2-Linked Hypertrophic Cardiomyopathy hiPSC-Derived Cardiomyocytes upon Metabolic MaturationSemantic proximity Read

AP-1 activation mediates post-natal cardiomyocyte maturationSemantic proximity Read

Current methods for the maturation of induced pluripotent stem cell-derived cardiomyocytesSemantic proximity Read

Defined MicroRNAs Induce Aspects of Maturation in Mouse and Human Embryonic-Stem-Cell-Derived CardiomyocytesSemantic proximity Read

A transcriptional enhancer regulates cardiac maturation.Semantic proximity Read

Single-cell analysis of murine fibroblasts identifies neonatal to adult switching that regulates cardiomyocyte maturationSemantic proximity Read

Cardiomyocyte Proliferation and Maturation: Two Sides of the Same Coin for Heart RegenerationSemantic proximity Read

Adult Human Heart ECM Improves Human iPSC-CM Function via Mitochondrial and Metabolic MaturationSemantic proximity Read

Metabolic reprograming-driven programmed embryonic cardiomyocyte senescence shapes cardiac chambersSemantic proximity Read

Maturation of human cardiac organoids enables complex disease modelling and drug discoverySemantic proximity Read