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Article

Senescent Microglia Represent a Subset of Disease-Associated Microglia in P301S Mice.

Journal of Alzheimer's disease : JAD - 1 Jan 2023

Ng Pei Y, Zhang Cheng, Li Hu, Baker Darren J

Abstract excerpt

BACKGROUND: The existence and contribution of microglia with senescent-like alterations in the pathogenesis of age-related neurodegenerative diseases like Alzheimer's disease (AD) have been suggested in recent years. However, the identification of this distinct microglial population in vivo has proven challenging, largely due to overlaps in the inflammatory phenotype of activated and senescent microglia....

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PMID: 37545233
DOI: 10.3233/JAD-230109
PMCID: PMC10848894

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