Article

Tau protein aggregation induces cellular senescence in the brain

2018-07-13

Abstract excerpt

Tau protein accumulation is the most common pathology among degenerative brain diseases, including Alzheimer’s disease (AD), progressive supranuclear palsy (PSP), traumatic brain injury (TBI) and over twenty others 1 . Tau-containing neurofibrillary tangle (NFT) accumulation is the closest correlate with cognitive decline and cell loss, yet the mechanisms mediating tau toxicity are poorly understood. NFT-containi...

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Literature Corpus work: e548f9cc-8abb-5d3e-aef1-db78ee7cb67f
DOI: 10.1101/369074

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