Article

MAIT cell deficiency exacerbates neuroinflammation in P301S human tau transgenic mice

2025-01-03

Abstract excerpt

The role of immune cells in neurodegeneration remains incompletely understood. Our recent study revealed the presence of mucosal-associated invariant T (MAIT) cells in the meninges, where they express antioxidant molecules to maintain meningeal barrier integrity. Accumulation of misfolded tau proteins are a hallmark of neurodegenerative diseases. The role of MAIT cells in tau-related neuroinflammation and neurodeg...

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Literature Corpus work: ffac9a7d-40cf-5e85-9f88-f47018b38922
DOI: 10.1101/2025.01.03.631124

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