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Article

Mice lacking a Myc enhancer that includes human SNP rs6983267 are resistant to intestinal tumors.

Science (New York, N.Y.) - 7 Dec 2012

Sur Inderpreet Kaur, Hallikas Outi, Vähärautio Anna, Yan Jian, Turunen Mikko, Enge Martin, Taipale Minna, Karhu Auli, Aaltonen Lauri A, Taipale Jussi

Abstract excerpt

Multiple cancer-associated single-nucleotide polymorphisms (SNPs) have been mapped to conserved sequences within a 500-kilobase region upstream of the MYC oncogene on human chromosome 8q24. These SNPs may affect cancer development through altered regulation of MYC expression, but this hypothesis has been difficult to confirm. We generated mice deficient in Myc-335, a putative MYC regulatory element that contains...

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Share to Adenomatous Polyposis Coli
Share to Cell Transformation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enhancer Elements, Genetic

Share to Intestinal Neoplasms

Share to Mice, Mutant Strains

Share to Proto-Oncogene Proteins c-myc

Source

Identifiers

PMID: 23118011
DOI: 10.1126/science.1228606

Genes

MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Mice lacking a Myc enhancer that includes human SNP rs6983267 are resistant to intestinal tumors.PMID 23118011Read ↗

Characterization of the colorectal cancer-associated enhancer MYC-335 at 8q24: the role of rs67491583.Semantic proximity Read ↗

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The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer.Semantic proximity Read ↗

Scarless genome editing reveals risk SNP rs6983267-G and lncRNA CCAT2 dictate targetable PI3K signaling dependence in WNT-dysregulated CRCSemantic proximity Read ↗

A polymorphic MYC response element in KBTBD11 influences colorectal cancer risk, especially in interaction with an MYC-regulated SNP rs6983267.Semantic proximity Read ↗

Mice deficient of <i>Myc</i> super-enhancer region reveal a differential control mechanism between normal and pathological growthSemantic proximity Read ↗

Long-range interaction and correlation between MYC enhancer and oncogenic long noncoding RNA CARLo-5.Semantic proximity Read ↗

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The common colorectal cancer predisposition SNP rs6983267 at chromosome 8q24 confers potential to enhanced Wnt signaling.Semantic proximity Read ↗

CFTR is a tumor suppressor gene in murine and human intestinal cancer.Semantic proximity Read ↗

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