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Article

Identification of focally amplified lineage-specific super-enhancers in human epithelial cancers.

Nature genetics - 1 Feb 2016

Zhang Xiaoyang, Choi Peter S, Francis Joshua M, Imielinski Marcin, Watanabe Hideo, Cherniack Andrew D, Meyerson Matthew

Abstract excerpt

Whole-genome analysis approaches are identifying recurrent cancer-associated somatic alterations in noncoding DNA regions. We combined somatic copy number analysis of 12 tumor types with tissue-specific epigenetic profiling to identify significant regions of focal amplification harboring super-enhancers. Copy number gains of noncoding regions harboring super-enhancers near KLF5, USP12, PARD6B and MYC are...

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Share to Enhancer Elements, Genetic
Share to MYC gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Neoplasms, Glandular and Epithelial

Source

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Identifiers

PMID: 26656844
DOI: 10.1038/ng.3470
PMCID: PMC4857881

Genes

MYC
KLF5
USP12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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