Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Shared requirement for MYC upstream super-enhancer region in tissue regeneration and cancer

3 Apr 2025

Abstract excerpt

Cancer has been characterized as a wound that does not heal. Malignant cells are morphologically distinct from normal proliferating cells but have extensive similarities to tissues undergoing wound healing and/or regeneration. The mechanistic basis of this similarity has, however, remained enigmatic. Here, we show that the genomic region upstream of Myc , which carries more cancer susceptibility in humans than...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to FOXO transcription factor regulation
Share to Hippo pathway signaling and YAP/TAZ

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40180576
DOI: 10.26508/lsa.202403090

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Shared requirement for MYC upstream super-enhancer region in tissue regeneration and cancerPMID 40180576Read ↗

Mice deficient of <i>Myc</i> super-enhancer region reveal a differential control mechanism between normal and pathological growthSemantic proximity Read ↗

Characterization of radioresistant epithelial stem cell heterogeneity in the damaged mouse intestineSemantic proximity Read ↗

Field cancerization in the GI tract.Semantic proximity Read ↗

A Spatial and Temporal Transcriptomic Atlas of Mouse Intestinal RegenerationSemantic proximity Read ↗

p53 promotes revival stem cells in the regenerating intestine after severe radiation injurySemantic proximity Read ↗

Oncogenic mutations drive intestinal cancer initiation through paracrine remodeling.Semantic proximity Read ↗

Transcriptome of the murine duodenum during recovery after a lethal dose of total body irradiationSemantic proximity Read ↗

LGR5+ Intestinal Stem Cells Display Sex Dependent RadiosensitivitySemantic proximity Read ↗

LGR5+ Intestinal Stem Cells Display Sex-Dependent RadiosensitivitySemantic proximity Read ↗

LGR5+ Intestinal Stem Cells Display Sex Dependent RadiosensitivitySemantic proximity Read ↗

Organoids Reveal That Inherent Radiosensitivity of Small and Large Intestinal Stem Cells Determines Organ SensitivitySemantic proximity Read ↗

Wnt/β-catenin mediates radiation resistance of Sca1+ progenitors in an immortalized mammary gland cell lineSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.