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Chromosome 8q24-Associated Cancers and MYC

1 Jun 2010

Abstract excerpt

Genome-wide association studies (GWAS) have successfully identified common polymorphisms that are strongly associated with many traits, including cancer. A gene desert located on chromosome 8q24 is associated with multiple cancer types. One of the closest genes is the MYC proto-oncogene. Investigations are now turning toward a mechanistic understanding of these (and other) risk loci. Recent studies demonstrate...

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PMID: 21779458
DOI: 10.1177/1947601910381380

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Related research

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Research trail→

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Chromosome 8q24-Associated Cancers and MYCPMID 21779458Read ↗

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Lessons from functional analysis of genome-wide association studies.Semantic proximity Read ↗

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The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer.Semantic proximity Read ↗

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MYC association with cancer risk and a new model of MYC-mediated repression.Semantic proximity Read ↗

Mice deficient of <i>Myc</i> super-enhancer region reveal a differential control mechanism between normal and pathological growthSemantic proximity Read ↗

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Meta-analysis of 8q24 for seven cancers reveals a locus between NOV and ENPP2 associated with cancer development.Semantic proximity Read ↗

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