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Article

Oncogenic super-enhancer formation in tumorigenesis and its molecular mechanisms.

Experimental & molecular medicine - 1 May 2020

Jia Qunying, Chen Shuhua, Tan Yuan, Li Yuejin, Tang Faqing

Abstract excerpt

Super-enhancers (SEs) consist of a cluster of many enhancers bound to a great number of transcription factors. They are critical cis-regulatory elements that determine the identity of various human cell types. During tumorigenesis, DNA mutations and indels, chromosomal rearrangements, three-dimensional chromatin structural changes, and viral infections mediate oncogenic SE activation, and activated SEs have been...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32382065
DOI: 10.1038/s12276-020-0428-7
PMCID: PMC7272638

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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