Article

An InDel Genomic Variant within a Bifunctional Super-Enhancer for LINC00636 and CD47 Regulation in Breast Cancer

2025-11-07

Abstract excerpt

<h4>SUMMARY</h4> Highly accessible genomic super-enhancers often drive tumor-promoting programs, yet the impact of genomic variation within these regulatory elements remains unclear. Here, we identified a bifunctional super-enhancer that regulates the expression of cancer-promoting genes LINC00636 and CD47 in breast cancer. We discovered that a common germline insertion variant within the super-enhancer is associ...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 404d3eef-4a7f-583f-8d77-5718e8201056
DOI: 10.1101/2025.11.05.684493

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

An InDel Genomic Variant within a Bifunctional Super-Enhancer for LINC00636 and CD47 Regulation in Breast CancerDOI 10.1101/2025.11.05.684493Read

An InDel Genomic Variant within a Bifunctional Super-Enhancer for LINC00636 and CD47 Regulation in Breast CancerSemantic proximity Read

A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancerSemantic proximity Read

Cis-acting Super-Enhancer lncRNAs as Biomarkers of Early-Stage Breast CancerSemantic proximity Read

A new class of constitutively active super-enhancers is associated with fast recovery of 3D chromatin loopsSemantic proximity Read

Super-enhancer profiling reveals ThPOK/ZBTB7B, a CD4+ cell lineage commitment factor, as a master regulator that restricts breast cancer cells to a luminal non-migratory phenotypeSemantic proximity Read

Super-enhancers in the control of cell identity and disease.Semantic proximity Read

NSMCE2, a Novel Super-Enhancer-Regulated Gene, is Linked to Poor Prognosis and Therapy Resistance in Breast CancerSemantic proximity Read

Super-enhancer profiling reveals ThPOK/ZBTB7B, a CD4 <sup>+</sup> cell lineage commitment factor, as a master regulator that restricts breast cancer cells to a luminal non-migratory phenotypeSemantic proximity Read

Epigenetic changes with age primes mammary luminal epithelia for cancer initiationSemantic proximity Read

Super-enhancer profiling reveals ThPOK/ZBTB7B, a CD4+ cell lineage commitment factor, as a master regulator that restricts breast cancer cells to a luminal non-migratory phenotype.Semantic proximity Read

Epigenomic mapping identifies a super-enhancer repertoire that regulates cell identity in bladder cancers through distinct transcription factor networksSemantic proximity Read

Mechanism of ERBB2 gene overexpression by the formation of super-enhancer with genomic structural abnormalities in lung adenocarcinoma without clinically actionable genetic alterations.Semantic proximity Read