Article

Deletions Rate-Limit Breast and Ovarian Cancer Initiation

2024-10-21

Abstract excerpt

<h4>ABSTRACT</h4> Optimizing prevention and early detection of cancer requires understanding the number, types and timing of driver mutations. To quantify this, we exploited the elevated cancer incidence and mutation rates in germline BRCA1 and BRCA2 (gBRCA1/2) carriers. Using novel statistical models, we identify genomic deletions as the likely rate-limiting mutational processes, with 1-3 deletions required to...

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Literature Corpus work: 115f2790-4cd5-567d-85bd-c8469ebe63df
DOI: 10.1101/2024.10.17.618945

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