Article

Estimating the carcinogenesis timelines in early-onset versus late-onset cancers and changes across birth cohorts

2025-08-27

Abstract excerpt

Understanding the timing of key mutational events in cancer development is critical for informing cancer prevention and detection strategies, particularly for early-onset cases that have increased in recent years. Yet intermediate mutational events are challenging to observe in humans. Here, we extend a tumor kinetic model we recently developed and long-term cancer registries data to estimate the expected timing o...

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Identifiers and source

Literature Corpus work: 76db6f1b-0b65-51ca-a182-b8e4e43890db
DOI: 10.1101/2025.08.25.25334404

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